We determined the macroscopic limit for phase synchronization of cellular clocks in an artificial tissue created by a “big chamber” microfluidic device to be about 150,000 cells or less. The dimensions of the microfluidic chamber allowed us to calculate an upper limit on the radius of a hypothesized quorum sensing signal molecule of 13.05 nm using a diffusion approximation for signal travel within the device. The use of a second microwell microfluidic device allowed the refinement of the macroscopic limit to a cell density of 2166 cells per fixed area of the device for phase synchronization. The measurement of averages over single cell trajectories in the microwell device supported a deterministic quorum sensing model identified by ensemble methods for clock phase synchronization. A strong inference framework was used to test the communication mechanism in phase synchronization of quorum sensing versus cell-to-cell contact, suggesting support for quorum sensing. Further evidence came from showing phase synchronization was density-dependent.
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Al-Omari, Ahmad M. ; Griffith, James ; Scruse, Ashley ; Robinson, Robert W. ; Schuttler, Heinz-Bernd ; Arnold, Jonathan ( , IEEE Access)
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Deng, Zhaojie ; Hwei Cheong, Jia ; Caranica, Cristian ; Wu, Lingyun ; Qiu, Xiao ; Judge, Michael T. ; Hull, Brooke ; Rodriguez, Carmen ; Griffith, James ; Al-Omari, Ahmad ; et al ( , IEEE Access)
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Deng, Zhaojie ; Arsenault, Sam ; Caranica, Cristian ; Griffith, James ; Zhu, Taotao ; Al-Omari, Ahmad ; Schüttler, Heinz-Bernd ; Arnold, Jonathan ; Mao, Leidong ( , Scientific Reports)